Aging is a symptom of Hutchinson-Gilford Syndrome, also known as childhood progeria, a genetic disease first reported by Hutchinson in 1886. Progeria patients’ body aging process is 5 to 10 times faster than normal, the patient looks like an old man, the organs also quickly decline, resulting in a decline in physiological functions. Signs include thinness, hair loss and late teething. Children with this rare disease can look as if they are in their 60s or 70s, even though they are only 16 years old. Most of them die from diseases of aging, such as cardiovascular disease, for which there is no effective treatment, but only medication. Although the disease is a congenital disorder, it is not certain whether it is autosomal recessive or dominant. The disease is a syndrome characterized by delayed development and progressive age-related degenerative changes that occur in infancy. The most characteristic clinical manifestations of premature aging resulting in an aged appearance are thinning, tense, dry, and wrinkled skin. Brown spot pigmentation is seen in many areas. The skin of the lower abdomen, thighs and buttocks has a scleroderma-like appearance. Superficial veins are evident in these areas and sweating is reduced. The eyebrows and eyelashes are absent and the fontanelle is bulging. The tip of the nose is hooked like a bird’s beak. Mild Raynaud’s phenomenon in the midface and nasolabials, thin lips, protruding ear tips with small earlobes, and malnourished nails. Children with pale appearance due to progeria are often normal in infancy or have only scleroderma-like symptoms. Midface bruising and a hooked nose often suggest the possibility of the disease. The symptoms become more pronounced around the age of 1 year and present with various characteristic manifestations until the second year. Patients with this disease generally do not have abnormalities of the thyroid, parathyroid, pituitary, or adrenal glands. However, the basal metabolic rate is increased and blood lipids are abnormal. Patients with progeria may develop atherosclerosis. Due to cardiovascular and cerebrovascular lesions often die young. The physical aging process is 5 to 10 times faster than normal. Patients look like the elderly and their organs decline rapidly, resulting in a decline in physiological function. Signs include thinness, hair loss and late teething. These can be used as a basis for diagnosis.