Staying up late for a long time can cause endocrine disorders, decreased immune function, neurasthenia, hypertension and other diseases, and in serious cases, may cause sudden death. 1. Endocrine disorders: staying up late for a long time can cause endocrine disorders, menstrual disorders, acne, and even amenorrhea and other symptoms. 2. Decrease in immune function: Staying up late can reduce the body’s resistance, especially the elderly, children and other special groups, more likely to have low resistance, causing diseases. 3. Neurasthenia: long-term stay up late, can make the body’s biological clock disorders, causing insomnia, neurasthenia and other symptoms. 4. Hypertension: long-term stay up late, the body’s neuroendocrine system dysfunction, sympathetic nerve excitation, thus causing increased blood pressure. Long-term stay up late on the human body is more harmful, usually live a regular routine, if not the need for work, it is generally not recommended to stay up late for a long time.