The increase of serum creatine kinase can be seen in myocardial infarction, myocarditis, muscle lesions, postoperative changes, etc. According to the different diseases, different treatments can be used, such as drugs, surgical treatment, and so on. 1. Acute myocardial infarction: rest, relief of anxiety to prevent adverse stimuli, oxygen inhalation; can take drugs β-receptor antagonist such as metoprolol to reduce pain; take aspirin and other antiplatelet drugs; 12 hours of coronary intervention and so on. 2. Myocarditis: the most common is due to viral infection, the treatment is mainly aimed at the left heart insufficiency supportive therapy such as the use of diuretics such as hydrochlorothiazide, etc. as appropriate. 3. Muscle disease: such as periodic paralysis, etc. should take appropriate amount of potassium chloride. 4. Thrombolytic therapy: surgical treatment “Creatine kinase helps to determine the reperfusion situation after thrombolytic therapy and does not need to be treated; cardiac or non-cardiac surgery will lead to an increase in creatine kinase, which is a normal phenomenon and does not require special treatment. When elevated serum creatine kinase is found, the cause should be identified and treated promptly to prevent cardiac arrest.