The most common disease is herpes zoster. The blisters are distributed unilaterally along people’s limbs and clustered together, which is called clustered distribution, and the pain is pins and needles or burning, not persistent pain. The pain is pins and needles or burning, not constant pain. Blisters with pain are caused by infection with a virus, varicella zoster virus, which mainly occurs in adults and develops when resistance and immunity are low, seriously affecting people’s quality of life. The pain is more obvious at night. It is recommended to go to the dermatology department of the hospital as soon as possible after the occurrence of the above situation.