Clinically, if the patient is in the state of calcium deficiency for a long time, it will lead to osteoporosis and suffer from osteoporosis. There will be localized muscle nutritional disorders, resulting in localized pain, muscle atrophy, muscle weakness, etc. For example, if calcium deficiency occurs in the lumbar vertebrae, the patient will be prone to lumbar or thoracic vertebrae compression fracture, and the patient will be prone to hunchback and other phenomena. If the patient has calcium deficiency in the knee joint, the patient will develop osteoarthritis or osteoporosis of the knee joint. The patient will feel pain and swelling in the knee joint, and in serious cases, deformation of the knee joint will occur, and this phenomenon will be aggravated when the patient’s knee joints are loaded with weight or after catching a cold. Therefore, patients with calcium deficiency should be treated in a timely manner and given calcium supplementation.