Albumin is the most important protein in human plasma, which can maintain the nutrition and osmotic pressure of the body, with a concentration of about 38-48g/L, accounting for about 52%-68% of the total plasma protein.
The serum albumin-to-globulin ratio is clinically significant, with a normal albumin-to-globulin ratio of (1.5-2.3):1. An increase in the ratio may indicate overnutrition, which is common in immunoglobulin deficiency.
A decrease in the ratio of albumin to globulin may be due to a decrease in albumin, which suggests that the body may be experiencing abnormalities such as decreased hepatic synthesis, increased extravascular leakage, gastrointestinal inflammation, cirrhosis of the liver, heartburn, and malignant tumors, or an increase in globulin, such as an increase in antibodies caused by infectious diseases or an increase in abnormal proteins caused by bone marrow tumors.
Decrease in serum albumin and decrease in albumin to globulin ratio are clinically important in reflecting the degree of liver function in cirrhosis. Therefore, when there is a decrease in the ratio, further examination and treatment should be done under the guidance of a doctor.