The fact that the new coronavirus is not disappearing may be mainly related to its infectiousness, global situation, specific drugs, survival mode, and mutation. 1. Infectious: The new coronavirus is highly infectious. It can cause infection through the respiratory tract and contact. Compared with other viruses, it is highly infectious. 2. Global epidemic situation: at present, although it is possible to achieve local zero growth, but the pressure of overseas importation is great and the global epidemic is severe, which is also the main factor that can not be completely eliminated. 3. Effective drugs: At present, there is no clinical effective drug that can be widely used, nor can it provide effective treatment for the new coronavirus. 4. Survival mode: The new coronavirus can attach to the surface of clothes, vegetables, fruits, frozen foods, etc., which makes it easy to spread. 5. Mutation: The new coronavirus strains are constantly mutating, such as Delta and Omicron strains. The constant change of virus leads to increasing difficulty in prevention and control. It is recommended that the population comply with the outbreak prevention and control requirements and work together to fight the outbreak.