Repeated fever with enlarged lymph nodes may be caused by infectious diseases such as lymphadenitis and tuberculosis, or it may be a manifestation of blood diseases such as leukemia. 1. Lymphadenitis: For lymphadenitis caused by infection, patients will have swollen lymph nodes accompanied by different degrees of fever. Usually after the cause of infection is clarified and antibiotics or antiviral drugs are used, the 2. Tuberculosis: Patients with tuberculosis may present with enlarged lymph nodes with recurrent low-grade fever, weight loss and night sweats. Such patients should first be evaluated for a complete blood count, chest X-ray, and tuberculin skin test. 3. Leukemia: Enlarged lymph nodes and recurrent fever can also be seen in patients with leukemia. The early presentation of leukemia patients is similar to that of a cold, but with recurrent fever and enlarged lymph nodes, and treatment with conventional medications is often ineffective. These patients should undergo bone marrow aspiration. For patients with enlarged lymph nodes and recurrent fever, it is recommended to consult a doctor in time to find out the cause and then treat the cause.