Psoriasis, also known as psoriasis, tends to cause nail changes, the most common manifestation of which is thimble-like nails, that is, dents on the nail surface. The nail changes can return to normal after treatment of psoriasis, so the treatment of nail changes in psoriasis also means active treatment of psoriasis. The treatment of psoriasis commonly used are Avion capsule, given 30-60mg per day for two months, gradually reduce the amount can be, with Avion capsule need to pay attention to monitor blood lipids and liver function, at the same time, because Avion capsule has teratogenic effect, so pregnant women and lactating women are not allowed to use. For severe psoriasis, methotrexate, cyclosporine and tretinoin can also be given as treatment. Now there are also new biological agents, such as infliximab, etanercept, adalimumab, etc., which need to be combined with the characteristics of the rash and the patient’s own situation to choose the appropriate method of treatment.