Sitting with a feeling of pressure on the stomach can be caused by a variety of reasons, generally considered overfeeding, indigestion, gastrointestinal dysfunction, chronic gastritis, peptic ulcer, stomach tumors and other causes, need to be based on the different causes of the patient’s physician to take the appropriate treatment measures and methods. 1. Eating too much: when the human body does not pay attention to timing and quantitative eating, eating too much, there can be a sense of fullness in the upper abdomen. 2. Indigestion: due to overeating and not paying attention to eating habits, a feeling of fullness in the epigastric region, accompanied by bloating, nausea, vomiting and other symptoms. 3. Gastrointestinal dysfunction: due to excessive mental stress and inattention to dietary habits, epigastric discomfort, accompanied by abdominal distension, abdominal pain and other symptoms. 4. Chronic gastritis: due to inattention to dietary and living habits, epigastric discomfort, accompanied by heartburn, acid reflux and other symptoms. 5. Peptic ulcer: it can be manifested as periodic and rhythmic epigastric pain and discomfort, accompanied by heartburn, acid reflux and other symptoms. 6. Stomach tumor: mostly seen in stomach cancer, due to tumor erosion and compression, epigastric discomfort may occur, accompanied by anemia, emaciation, vomiting blood, blood in stool and other symptoms. If the symptoms continue to be unrelieved, it is recommended to go to the hospital in time to get a clear diagnosis of the cause of the disease and then carry out targeted treatment.