Abnormal perfusion of the left lobe of the liver can be caused by many different reasons. If the abnormal perfusion of the liver is caused by congenital diseases such as vascular malformations and arteriovenous fistulas, no special treatment is needed if there is no liver function impairment or other abnormal symptoms. If it is caused by more serious cirrhosis and certain liver malignant tumors, it is more serious and requires medication and surgery. 1. Congenital factors: abnormal perfusion of the left lobe of the liver caused by congenital diseases such as vascular malformation and arteriovenous fistula. If the patient has no clinical symptoms and liver function abnormalities, no special treatment is needed and regular follow-up observation is sufficient. 2. Cirrhosis, malignant tumor: Cirrhosis develops from viral hepatitis, alcoholic hepatitis, etc., so that the liver is severely damaged, and antiviral drugs, such as entecavir and tenofovir, can be considered. Alcoholic liver disease patients should quit drinking immediately, and it is recommended to standardize the medication under the guidance of a doctor, do not take it privately. Liver malignant tumors causing abnormal perfusion in the left lobe of the liver should be considered for surgical resection, such as partial hepatectomy, hemihepatectomy, etc., and chemotherapy (cisplatin, fluorouracil, etc.), radiotherapy, targeted therapy (sorafenib, lenvatinib, etc.) should be taken according to the postoperative pathology. It is recommended that patients go to the hospital to clarify the causes of abnormal perfusion of the left lobe of the liver and under the guidance of the doctor to carry out appropriate treatment.