The platelet volume distribution width is an indicator of the size and dispersion of platelet volume in peripheral blood, and whether the volume size of platelets in peripheral blood is uniform. A high platelet volume distribution width indicates that the volume size of platelets in peripheral blood varies greatly, with very large platelets and very small platelets, with a wide range of sizes. Clinically, high platelet volume distribution width is commonly seen in the following diseases: acute myeloid leukemia, megaloblastic anemia, chronic granulocytic leukemia, and giant platelet syndrome. Also, some thrombotic diseases may also have high platelet volume distribution width, so if you have high platelet volume distribution width, you should be alert to whether it is caused by the above diseases and need to go to the hematology department for a comprehensive examination.