The following reasons are common for patients’ left middle toe pain: First, local trauma: such as heavy object smashing or joint sprain, which can lead to pain, swelling and activity limitation of the left middle toe, and the patient can’t even walk and exercise with weight bearing, and sometimes the X-ray may also find localized fracture. Secondly, degenerative changes of interphalangeal joints: old patients are prone to degenerative osteoarthritis of the left middle toe joint, patients will have pain, swelling and deformity of the middle finger joints, and X-ray filming will find the joint space narrowing and joint deformation. When pain occurs in the middle toe of the left foot, it must be diagnosed and treated at an early stage in order to get rapid relief of clinical symptoms. In the patient’s normal life, attention should be paid to avoiding trauma and serious degeneration, preventing the recurrence of symptoms, and wearing wide-toe shoes and soft-soled shoes is conducive to the prevention of symptoms. Thirdly, it is also necessary to exclude some immune diseases such as gout, which requires blood tests for uric acid.