Abrupt discontinuation of paliperidone may cause withdrawal reactions such as palpitations and panic attacks. Paliperidone is an antipsychotic drug that is mainly used for the treatment of schizophrenia in the acute and maintenance phases. As the drug has a certain degree of dependence, in the process of taking the drug, if the drug is suddenly stopped, it is easy to produce drug withdrawal reactions, such as palpitations, panic, body trembling, heartburn, anxiety, impulsivity and other symptoms. Taking paliperidone must be instructed by the doctor to adhere to the drug, if the drug after a period of time after the condition has been significantly relieved, not to arbitrarily stop taking the drug on their own, should be under the guidance of the doctor, gradually reduce the dosage of the drug to the discontinuation of the drug, during which there is a discontinuation of the drug process, to avoid the occurrence of withdrawal reactions.