Rheumatology is a clinical medicine discipline that started late and the current understanding of rheumatic diseases is still shallow. The pathogenesis of most rheumatic diseases is related to abnormalities of the immune system, so they are also called rheumatic-immune diseases. Rheumatic diseases contain more than 100 diseases in 10 major categories. For example, common diseases include rheumatoid arthritis, dry syndrome, ankylosing spondylitis, systemic lupus erythematosus, gout, osteoarthropathy, rheumatic fever, and so on. Since most of them have unknown causes, prolonged illness, extensive disease, and severe pain, patients with rheumatic disease symptoms are not sure which department to consult. It is easy to miss the diagnosis and misdiagnosis. If a patient has the following symptoms, suggesting that he or she may have rheumatic diseases, he or she should go to the rheumatology department of the hospital promptly. 1, pain: In the pain of rheumatic diseases, pain originating from joints and their accessory structures is the most common. Arthralgia, neck and shoulder pain, low back pain, heel pain are often the main manifestations of rheumatic diseases, sometimes accompanied by swelling of the joints. For example, rheumatoid arthritis often has symmetrical joint swelling and pain, finger joints, wrist joints are particularly obvious; ankylosing spondylitis has low back pain, aggravated at rest, may be accompanied by heel pain, red eyes; rheumatic polymyalgia has neck and shoulder pain, pain in the limb band muscles and muscle weakness. 2, unexplained fever: fever is a common symptom of rheumatic diseases, can be low fever, moderate fever, can also be high fever, often can be manifested as irregular fever, generally no chills, antibiotics are ineffective, while the blood sedimentation is fast. For example, systemic lupus erythematosus, adult Steele’s disease, acute neutrophilic febrile dermatosis, and lipofuscinosis can all have fever as the first symptom. 3. Skin and mucous membrane symptoms: unexplained rash, photosensitivity, oral ulcers, vulvar ulcers, fundus symptoms, reticular cyanosis, skin ulcers, etc. can appear in SLE, dermatomyositis/polymyositis, leukodystrophy, dry syndrome, etc. 4. Raynaud’s sign: whitening of the finger (toe) ends when exposed to cold or emotional agitation, followed by purple, red or accompanied by numbness and pain at the finger (toe) ends, and in severe cases, skin ulceration may occur. It can be seen in scleroderma, mixed connective tissue disease, systemic lupus erythematosus, etc. 5, muscle pain, muscle weakness: If there is muscle pain, weakness, with elevated muscle enzymes, electromyography shows myogenic damage, etc., suggesting a rheumatic disease. Such as dermatomyositis / polymyositis, mixed connective tissue disease, systemic lupus erythematosus, etc. 6, other symptoms: dry mouth, dry eyes, hair loss and other symptoms dry syndrome is common. 7, abnormal blood immune indicators: rheumatoid factor, blood sedimentation, anti-nuclear antibody profile, anti-platelet antibodies, anti-cardiolipin antibodies, immunoglobulins and other abnormalities, suggesting rheumatic diseases. In addition, some rheumatic diseases, especially autoimmune connective tissue diseases such as systemic lupus erythematosus and rheumatoid arthritis, can have damage to multiple organs, such as manifestation of cardiac inflammation (pericarditis, myocarditis, endocarditis), kidney damage (proteinuria, hematuria, swelling, hypertension, renal failure), hematological system (leukopenia, erythrocytopenia, thrombocytopenia, capacitated blood, etc.), respiratory system ( interstitial pneumonia, pulmonary hypertension, pleural effusion), digestive system (liver function impairment, jaundice), etc. If any of the above conditions appear must be taken seriously, promptly to the hospital rheumatology department, to find the relevant experts early diagnosis, early treatment.