Early wakefulness may be caused by neurosis or may be caused by depression. It may also be caused by prolonged mental tension, stress or overexertion. Patients with neurasthenia mainly manifest early awakening during sleep, and can also appear to dream more during sleep. Some patients can show difficulty in falling asleep, which affects the quality of sleep. Patients with depression mainly show early awakening during sleep and more dreaming during sleep, and may also show psychological symptoms, which can manifest as depressed mood, disinterest in anything, and in severe cases, may cause the desire to lighten up. For patients with neurasthenia, the main thing is to give oral glutamate, tranquilizer and brain tonic liquid, nourishing blood and clearing brain granules, and also oral sour date oral liquid and heart tranquilizer tablets for regulation. Patients with depression can take oral citalopram for antidepressant treatment, and can also apply Dextran for.