Hepatitis B in pregnancy is more common in China and is the most common liver disease complicating pregnant women. Hepatitis B is transmitted through blood and sexual contact, and the prevalence of pregnancy-associated viral hepatitis B ranges from 0.025% to 1.6%, which can lead to postpartum hemorrhage and diffuse intravascular coagulation in pregnant women, and perinatally to preterm labor, intrauterine growth retardation, stillbirth, neonatal death, and mother-to-child transmission. Occult infection can also lead to chronic disease in the mother and offspring. The management of pregnancy starts with weighing the possibility of continuing the pregnancy according to the type of viral hepatitis and its condition, and treating it accordingly at different times of the pregnancy. The principle of treatment is the same as non-pregnancy, there is still no specific treatment, but we should be vigilant about the deterioration of liver function in late pregnancy, turning into severe hepatitis. In early pregnancy, viral hepatitis can aggravate pregnancy reactions, such as nausea, vomiting increased, seriously affecting eating. Acute hepatitis B in early pregnancy should be actively given treatment, and abortion should be performed after the condition improves. Although there is no clear evidence that HBV can cause intrauterine malformations, the chance of vertical transmission from mother to child is high, and prevention and reduction of morbidity should be actively pursued. HBV infection has been proved to carry virus from female oocytes and male sperm cells to cause germline transmission and intrauterine transmission, therefore, before preparing for pregnancy, both parties should do the hepatitis B and C viral markers, such as HBsAg or HBeAg or HBc positivity, both need to do the HBV-DNA assay, such as the hepatitis C antibody IgM (+), then the HCV-RNA assay and treatment. And guide the knowledge of preconception and pregnancy hygiene, reduce the infection of all kinds of viral hepatitis, and actively treat chronic hepatitis if any. Enhancement of pregnancy testing: detection of viral hepatitis during pregnancy, early diagnosis and active treatment. All pregnant women, regardless of symptoms of viral hepatitis and history of infection, should routinely do hepatitis A, B and C serum marker tests, and those who are positive should do specific DNA or RNA measurement to estimate the risk of vertical transmission.