The sequelae of long-term consumption of rivaroxaban include bleeding, hepatitis, kidney function impairment, etc., so it should be used in a standardized manner under the guidance of a doctor. Rivaroxaban is used clinically to treat thrombophilia and prevent thrombosis, including venous thrombosis in adults, after hip and knee arthroplasty, etc. It can effectively prevent the formation of thrombus and reduce the risk of systemic embolism. However, in the process of long-term use, rivaroxaban may also have some significant adverse reactions, including bleeding caused by abnormal coagulation function such as cerebral hemorrhage, epidural hematoma, etc. It may also increase the metabolic burden of liver and kidney and cause damage to liver and kidney function. Therefore, rivaroxaban should be used in strict compliance with the doctor’s instructions, and when adverse reactions occur, it should be consulted in time, and those who are allergic to the drug should be prohibited from using it, and at the same time, regular review should be carried out to avoid the occurrence of serious after-effects.