Compound ketoconazole cream is generally indicated for fungal infections of the skin. Since the main ingredient, ketoconazole, has obvious fungicidal effect, the therapeutic effect is still mainly antifungal. Compound ketoconazole cream is mainly used for superficial skin fungal infections such as ringworm, ringworm of the hands, feet, body and femur. Ketoconazole is an arsenic-based antifungal agent. It has antibacterial and fungicidal effects on dermatophytes, yeasts (Candida spp., Cryptococcus spp., Cryptococcus spp.), biphasic fungi and fungal phyla. Its mechanism of action is to interfere with the cytochrome P450 activity of fungi in a highly selective manner, thereby inhibiting the biosynthesis of ergosterol on the fungal cell membrane. Clobetasol propionate is a potent corticosteroid for external use. It has rapid action, strong capillary constriction and anti-inflammatory effects. It should not be used for a long time because continued use may lead to hormone dependence and the formation of hormone-dependent dermatitis.