The main causes of blisters on the buttocks include the following: first, viral infections caused by sexually transmitted diseases, mostly represented by condyloma acuminatum, will form many blisters around the anus and on the buttocks, which are highly contagious and cause pain and itching symptoms; second, perianal eczema, perianal eczema will form many small papules and rice-grain blisters on the buttocks, and itching and redness; third, fire, mainly due to long-term poor diet; Third, fire, mainly due to long-term poor diet, the usual intake of too much spicy, irritating food and a lot of alcohol is the main cause of fire; fourth, perianal disease, including hemorrhoids and perianal abscess, will form abscesses or lumps around the anus, and cause itching and pain around the anus.