It is not possible to generalize how many times a single dose of simethicone can be used, depending on the dosage used. In general, a single dose can be used at least 4 times. The recommended starting dose of simethicone is 0.25 mg once weekly; it is increased to 0.5 mg once weekly after 4 weeks of continuous use, and the dose can be adjusted to 1 mg once weekly after at least 4 weeks of use, while the specification of simethicone is 1.34 mg/ml, and there are 3 ml in each tube. Common adverse reactions during administration are symptoms of gastrointestinal irritation, such as nausea, diarrhea, and vomiting. Note that the drug is contraindicated in individuals with a family or medical history of medullary thyroid cancer, those with type 2 multiple endocrine neoplasia syndrome, and those who are allergic to this drug. Simeglutide must be used under medical supervision.