Generally speaking, high bile acids have no effect on the fetus when taking medication as prescribed by the doctor. Liver function test during pregnancy suggests high bile acid, consider intrahepatic cholestasis in pregnancy, is a unique complication of pregnancy, due to the increased risk of perinatal occurrence of fetal distress, fetal death in utero, etc., so once the diagnosis is clear, comply with the doctor’s advice to give ursodeoxycholic acid and other medication to control the level of bile acid, generally have no effect on the fetus. Contraindications such as severe hepatic hypoplasia should be excluded before taking Ursodeoxycholic Acid, and adverse reactions such as constipation, allergy and headache, dizziness may occur after taking it. During the treatment period, liver function changes should also be reviewed according to the changes in the condition, and maternity check should be strengthened during pregnancy, fetal heartbeat and movement changes should be closely monitored, and the pregnancy should be terminated at the right time according to the condition of the mother and fetus, so as to ensure the safety of the mother and the baby.