High thyroid stimulating hormone levels in pregnancy may be associated with hypothyroidism, etc. Prompt medical attention is recommended. If hypothyroidism is diagnosed, treatment should be decided based on serum TSH level and whether TPOAb is positive or not. TSH> the upper limit of the pregnancy-specific reference range (or 4.0 mU/L) is recommended regardless of whether TPOAb is positive or not. Thyroid hormones are critical to the fetus and are associated with neurologic and growth development, and they are supplied by the mother. High thyroid stimulating hormone may be associated with hypothyroidism, which can adversely affect fetal growth and intellectual development, and may even lead to malformations, and has also been associated with miscarriage and preterm labor. TSH>upper limit of pregnancy-specific reference range (or 4.0mU/L), regardless of whether TPOAb is positive or not, levothyroxine sodium tablets are recommended.TSH>2.5mU/L and lower than the upper limit of pregnancy-specific reference range (or 4.0mU/L), accompanied by TPOAb positivity, consider levothyroxine sodium tablets treatment. Pregnant women with high thyroid-stimulating hormone should go to the hospital and be treated under doctor’s supervision.