Moderate anemia is defined as hemoglobin between 60-90 g/L. For patients with moderate anemia, most of them have symptoms of anemia, such as general weakness, dizziness after activity or palpitations. Therefore, patients with moderate anemia need treatment. Moderate anemia is mainly treated symptomatically and etiologically. For symptomatic treatment, although the hemoglobin is not lower than 60g/L, for the elderly and those with more underlying diseases, even if the hemoglobin is above 60g/L, red blood cell transfusion is possible if the symptoms of anemia are severe. For etiological treatment, the treatment is mainly based on the cause of anemia. For example, iron deficiency anemia and megaloblastic anemia are treated with iron supplements, folic acid and vitamin B12. In the case of renal anemia, which is mainly due to decreased erythropoietin biosynthesis, erythropoietin may be given. In the case of aplastic anemia, immunosuppressive therapy is usually required. For anemia combined with an enlarged spleen, such as hereditary spherocytosis, splenectomy can be performed.