Recently, I heard from a patient that an 80-year-old academician in their unit was lost when he was out with his family, and by the time he was found, the old man had unfortunately passed away. With the acceleration of global aging, dementia has become a serious social problem. Although Alzheimer’s disease (as the name implies) is a common disease in the elderly population, some patients with early onset of the disease even start to develop in their 50s. Although there is no cure for Alzheimer’s disease worldwide, early use of symptomatic drugs such as memantine and cholinesterase inhibitors (e.g., donepezil) can be effective in early stage patients, and the progression of some patients will be slowed down, which will not stop the progression of the disease, but will at least partially improve the quality of life of patients and their families. If the disease progresses to the middle and late stages before treatment, the results are usually not good and the family burden and the patient’s quality of life will be seriously affected. Therefore, early recognition of Alzheimer’s disease and early treatment are very crucial. Alzheimer’s disease, medically known as “Alzheimer’s disease”, is characterized by progressive memory loss and is characterized by the inability to remember new events, such as repeating the same questions over and over again in a short period of time (without remembering that they have already been asked). In contrast, the memory of long-ago events, such as the names of classmates in elementary school, is still fresh in my mind, and therefore gives the impression to outsiders that I have no memory problems. The ability to learn new things is diminished, for example, it is difficult to learn how to use the remote control of a new TV or set-top box. The diminution of intelligence is uneven, with some aspects retained very well and others very poorly. It is like using a chalkboard eraser to wipe a handful of things on a blackboard full of things, and the areas that are not erased are well preserved. This is very confusing and is the reason why many family members ignore or do not pay attention to it, or even deny it when doctors suspect that they have Alzheimer’s disease, and wait until other symptoms, especially those of abnormal mental behavior, appear, or when wandering occurs, before waking up like a dream. Many elderly people do not look as “demented” as they think they are, and many of them still look kind, even elegant, and retain basic manners. So, what are the symptoms that indicate possible Alzheimer’s disease? The following are the ten most common symptoms: 1. Memory loss: often repeating things that have been said many times, forgetting whether they have eaten or taken medication, not remembering what was said on the phone. Difficulty in learning new things. Often forget to put salt in stir-fry or repeat salt, forget to turn off the gas after cooking or forget that something is cooking on the stove causing it to burn. 2. Inability to complete familiar tasks: Difficulty in doing things that could be done quickly in the past, inability to arrange what to do first and what to do later. Difficulty with daily chores, such as forgetting the steps to cook your best dish or making it less tasty than before. Doing things more slowly than before, often hesitating. 3. Difficulty in expressing yourself verbally: forgetting simple words, difficulty in finding words, difficulty in understanding what you say or write, forgetting the names of everyday objects. 4. Gradual confusion about time, place, or relationships of people: confusion about the change of seasons, not knowing what year it is or was. Getting lost in the neighborhood where you have lived for a long time. Confused about the relationship between relatives or friends you know very well, and confused about the relationship, even can’t recognize your son and grandson. 5. Decreased judgment: not being able to correctly judge the relationship between weather and clothing: wearing cotton clothes in the summer and single clothes in the winter. Cannot distinguish between truth and falsehood, easily misled by false propaganda and deceived. 6.Decline in comprehension or ability to arrange things rationally: can’t keep up with the ideas of other people’s conversations, can’t understand simple things; doesn’t prioritize things, often can’t pay bills on time. 7, often put things in the wrong place: put the iron in the washing machine, put the heater in the coat closet, hide food under the pillow or put it in the clothes pocket. 8.Behavior and emotional changes: depressed, indifferent, sometimes temperamental, behavior becomes childish 9.Change in personality: become suspicious, because forgetting often can not find things (mostly worthless things), they suspect that the nanny or daughter-in-law stole it, and firmly believe it. Before happy to help others, now become stingy and mean. 10. Lack of initiative: no more interest in previous hobbies, always sitting still, unwilling to go out for a walk, even needing to be rushed to eat. When the above symptoms or other unusual manifestations are found, it is best to take the elderly to a psychiatric hospital, or a psychiatric department of a general hospital, as soon as possible for evaluation and further examination by a professional doctor. If you have a family history of Alzheimer’s disease, such as parents, siblings, uncles, grandparents, aunts, uncles, etc., who have Alzheimer’s disease or are “old and confused”, you should go to the above mentioned institutions for screening as soon as possible, in addition to the general cognitive assessment. In addition to general cognitive assessment, it is advisable to undergo comprehensive blood tests and cranial MRI scans if possible, in order to understand brain degeneration and facilitate early intervention.