Drinking too much wine knee pain may be caused by gout, or it may have nothing to do with drinking, the patient himself suffers from chondromalacia patellae, knee osteoarthritis and other diseases caused by rheumatoid arthritis and other diseases. 1. Gout: the etiology and pathogenesis of gout have not been clarified, and it is considered to be caused by excessive uric acid. The main symptoms of patients are sudden pain in one or more joints, redness and swelling, elevated skin temperature, etc. Excessive intake of alcohol may aggravate the condition of patients and lead to symptoms of knee pain. 2. Chondromalacia patella: the pathogenesis of chondromalacia patella has not been fully clarified, considering biomechanical factors and diseases. The patient’s main symptoms are knee pain, knee dysfunction, etc. If the patient suffers from chondromalacia patellae, knee pain is not directly related to drinking too much alcohol. 3. Knee osteoarthritis: the cause of knee osteoarthritis is not clear, and is related to a variety of factors, such as age, obesity and so on. Patients will have joint pain, deformity, swelling, etc. If the patient himself suffers from knee arthritis, it will also lead to knee pain after drinking too much alcohol. 4. Other: rheumatoid arthritis, synovitis and other diseases can also lead to knee pain after drinking too much wine. When patients have symptoms of knee pain after drinking too much alcohol, they should consult a doctor in time and follow the doctor’s instructions for treatment.