The HFMD vaccine is generally recommended to start at 6 months of age. The HFMD vaccine is mainly used to prevent HFMD caused by EV71 infection. HFMD is a prevalent infectious disease in preschool children and is generally susceptible among children, making vaccination more important. The level of maternally transmitted EV71 antibodies in infants generally declines after birth and is lowest between 5 and 11 months of age, while the highest incidence of HFMD occurs between 6 months of age and 2 years of age, so it is then recommended to start the HFMD vaccine at 6 months of age, and it is generally encouraged to complete the vaccination program by 12 months of age in order to minimize the risk of developing HFMD. It is important to note that people who are allergic to vaccine components, patients with fever or acute illness, and patients with acute exacerbation of chronic diseases should not be vaccinated. It is recommended that you carefully consult your doctor about precautions and vaccination conditions before vaccination.