Rheumatic diseases, especially systemic lupus erythematosus and systemic vasculitis, often have renal involvement. The presence of hematuria and proteinuria is an important sign of renal involvement. Specialists often judge the efficacy of treatment and adjust medication based on the increase or decrease of urine protein. Urine protein results in routine urine tests are more commonly used for diagnosis and follow-up of outpatients than 24-hour urine protein quantification because they are economical and convenient. It is important to collect urine test specimens correctly.1. Time of urine collection: Any time of urine discharge can be used for routine laboratory tests. The first urine is sent for examination in the early morning for the observation of the results before and after the general kidney disease. 2, the amount of urine sent for examination: generally 5 to 10 ml, such as to measure the specific gravity of the urine can not be less than 50 ml. 3, the retention of urine specimens should be taken from the middle urine: that is, a part of the urine is first discharged and discarded to flush out the bacteria left in the urethra and front urethra, and then the middle urine is retained for examination. Care should be taken not to bring non-urinary components into the urine: for example, female patients do not mix in leukorrhea and menstrual blood (menstrual period is not advocated for routine urine tests), male patients do not mix in prostate fluid, etc.