Total bilirubin 25μmol / L, belongs to the high, not very serious, not terrible, may be physiological high, may also be pathologic, such as acute hepatitis, cholecystitis, etc., after treatment may be cured. 1. Physiological high: may be bad dietary habits, such as frequent drinking, etc., after doing strenuous exercise, resulting in total bilirubin appeared transiently high, stop drinking more rest can gradually return to normal, generally do not need treatment. 2. Pathologically high: (1) Acute hepatitis: if it is hepatitis B virus infection, lamivudine, entecavir and other antiviral treatment can be given to promote the total bilirubin to normal. (2) Cholecystitis: in case of acute cholecystitis, drugs such as cefuroxime and ursodeoxycholic acid tablets can be given to promote the decrease of total bilirubin. If the total bilirubin is high, it is recommended to consult a doctor to identify the cause of the disease and follow the doctor’s instructions.