Periapical infections need to be treated even if they are not painful. The absence of pain is only a change from the acute phase to the chronic phase, the lesion is still there, root canal treatment should be performed. In apical periodontitis, the pulp tissue in the pulp chamber is completely necrotic, and the necrotic material will seep out to the root tip to reach the periapical tissues. If the necrotic pulp tissue in the pulp chamber is not cleaned out in a timely manner, the irritation will persist, and the symptoms of inflammation in the periapical region cannot be effectively relieved, and the periapical periodontitis without pain also needs to be actively treated with root canal therapy. Root canal treatment mainly includes root canal preparation, root canal disinfection and medication exchange, root canal filling, etc. After root canal disinfection, the medication used for root canal filling can continuously play an anti-inflammatory role, so that periapical inflammation can be gradually eliminated. After two weeks, if there is no pain in the tooth, it is best to have a crown restoration, which can prevent the tooth from splitting. Even if the apical periodontitis is painless, it is still necessary to go to the hospital in time, and choose the best time for treatment under the advice of a professional physician, in order to facilitate the recovery of the inflammation.