A lot of coffee spots on the body need to consult a doctor in time for physical examination, histopathological examination and genetic test to confirm the diagnosis of the disease. 1. Physical examination: the doctor will observe the location, nature and shape of the lesions on the whole body to determine whether the lesions are consistent with cafe-au-lait spots. Generally speaking, café-au-lait spots are mainly light brown patches of varying sizes, from several millimeters to tens of centimeters; they are of various shapes, such as oval, round or irregular; the borders of the patches are clear, and the surfaces of the patches are smooth. 2. Histopathological examination: that is, under the microscope, observe whether the characteristics of local lesions are consistent with café-au-lait spots, which are caused by the increase of melanin in the epidermis, and the increase of the number of melanocytes in the basal layer can be seen. 3. Genetic test: if the diameter of cafe-au-lait spots is larger than 1.5cm and the number is more than six, it may be considered to be caused by neurofibromatosis, so it is necessary to carry out genetic test to clarify whether there is any gene mutation and whether there is any risk of heredity to the next generation. It is recommended that the patient should actively consult the doctor and follow the doctor’s instructions to carry out the appropriate examination and treatment.