People who have used Corkscrew for a lifetime are patients who have used Corkscrew for a long time. Long-term use of Corkscrew may cause habitual constipation, dependence on Corkscrew, localized intestinal mucosal injuries and abrasions, and other adverse reactions. 1. Habitual constipation: Glycerin in Corkscrew is highly absorbent, and frequent use will cause dryness of the intestinal wall, resulting in habitual constipation. 2. Dependence on corkscrew: long-term use of corkscrew will lead to the situation of not using corkscrew to defecate, resulting in dependence. 3. Local intestinal mucosal injury and abrasion: After using Corkscrew, due to the dryness and lack of water in the intestinal wall, the fecal friction stimulation will also lead to local mucosal injury and bleeding. The plastic at the end of the head of Keserol has a certain degree of hardness, often stimulate the anus, easy to lead to anal or rectal abrasions, and wounds in the excretory parts of the wound is more likely to be infected, not easy to recover. Keselu should be used under the guidance of a professional physician, and should not be used indiscriminately or long-term use.