Snake skin legs may be due to ichthyosis, dry eczema, atopic dermatitis and other diseases, there is no best treatment for snake skin legs, patients can take general measures for the cause of the disease, drug treatment. 1. Ichthyosis: snake skin legs may be caused by ichthyosis, patients can use petroleum jelly, urea cream, lactic acid ointment and other moisturizers under the guidance of a doctor, or topical retinoids, such as tazarotene, adapalene and so on. 2. Dry eczema: snake skin legs may also be caused by dry eczema, the patient needs to reduce the number of baths, bathing to avoid overheating of the water temperature, after the bath in a timely manner to apply emollient creams such as urea cream. If necessary, you can use topical glucocorticoid drugs, such as dinexed, halomethasone, etc., or oral antihistamine drugs, such as loratadine, cetirizine. 3. Atopic dermatitis: snake skin legs are also considered to be caused by atopic dermatitis, patients can follow the doctor’s instructions for external hydrocortisone, trimethoprim and other glucocorticosteroids, or external tacrolimus, pimecrolimus and other calcium-modulated neuralgia phosphoric acid inhibitors. At the same time, attention should be paid to keep the local skin moist. There are many causes of snake skin legs, it is recommended that patients identify the cause of the disease and actively cooperate with the doctor to take treatment measures. Drugs need to be used in accordance with medical advice.