Rheumatoid arthritis caused by leg soreness may be related to infection with group A beta-hemolytic streptococcus, and may be treated with attention to warmth and the use of non-steroidal anti-inflammatory drugs, glucocorticoids and other medications. Rheumatoid arthritis is due to the infection of group A type B hemolytic streptococcus, the immune response can involve the joints to cause joint swelling and pain, so rheumatoid arthritis can lead to leg soreness. Rheumatoid arthritis patients should pay attention to warmth and moisture when the disease involves the joints, cold and damp environment can easily lead to aggravation of symptoms. Clinically commonly used therapeutic drugs for non-steroidal anti-inflammatory drugs such as Loxoprofen sodium, etoricoxib and other non-steroidal anti-inflammatory drugs, the use of the need to pay attention to whether there is asthma, active ulcers, renal insufficiency and other contraindications to the existence of gastrointestinal and cardiovascular adverse reactions also need to be vigilant. For those with contraindications to NSAIDs or unsatisfactory efficacy, glucocorticoids such as prednisone and methylprednisolone may be applied. Rheumatoid arthritis patients are advised to go to the rheumatology and immunology department of regular hospitals and other related departments, follow the doctor’s instructions to standardize the diagnosis and treatment, do not self-medication.