Ollier’s syndrome is considered to be multiple endogenous chondromatosis. If asymptomatic, it is followed and observed without treatment; if severe, it requires surgical treatment. Multiple endogenous chondromatosis is a benign tumor that refers to abnormal cartilage development in multiple parts of the body. Due to the variability of multiple endogenous chondromatosis, it is difficult to treat every part of the chondroma, so usually no treatment is given to patients without clinical symptoms, but regular follow-up is needed to closely observe the changes of the condition. If the patient’s condition is serious, and painless lumps, obvious deformity or shortening of limbs have already appeared, the patient needs to undergo surgical treatment, and common surgical methods include osteotomy and orthopedic surgery, lesion resection, and so on. Studies have shown that multiple endogenous chondromatosis is prone to malignant changes, so once diagnosed, patients should strengthen their daily life management, avoid exertion, pay attention to warmth, rationalize work and rest arrangements, and keep a happy mood. Some patients also need to cooperate with doctors for functional recovery training to improve the quality of life.