The change of nasal discharge from clear to yellow is usually seen in bacterial infections. The common bacteria are Staphylococcus aureus or Streptococcus haemolyticus, and common diseases include acute rhinitis and acute sinusitis. These two bacteria are sensitive to penicillin as well as cephalosporins, so you can take cefuroxime, cefotaxime, cefixime, cefradine, amoxicillin, and penicillin V potassium tablets orally. If cephalosporin is allergic, then oral roxithromycin, azithromycin or erythromycin can be administered for treatment. If the effect of oral medication is poor, then infusion therapy can be performed. Generally, cefazolin sodium, ceftriaxone sodium, cefotaxime sodium, aminoglutethimide, meropenem, etc. Patients also need to use saline for repeated nasal rinsing twice a day, which can gradually heal in about a week. During the treatment period, patients need to drink more water, especially boiled water, eat more vegetables and fruits, not to stay up late and not to exert themselves.