If a patient has an enlarged heart and is in heart failure, how long he or she will live depends on the severity of the condition, whether the patient has taken the medications on time, and whether lifestyle interventions have been incorporated to improve the condition. For patients with severe heart failure, the one-year survival rate is about 50%. If the patient has only mild heart failure and is taking oral secondary prevention medications on time, a 5-10 year survival rate is possible. Patients with enlarged hearts are advised to take medications to prevent further enlargement of the heart, such as perindopril, spironolactone, and metoprolol. If necessary, patients are also advised to take medications like Nosyntropin, whose main ingredient is sacubitril valsartan, which is a relatively new drug in the clinic to prevent the progression of heart failure.