Calf pain after tiptoe may be caused by physiological factors such as running for a long time, or it may be caused by pathological reasons such as damage to the calf muscles or ligament strains. 1. Physiological factors: due to prolonged running, weight-bearing and other factors, can lead to calf muscle fatigue, increased metabolic products in the body, lactic acid buildup, can cause pain in the calf muscles, adequate rest, massage localization can be gradually recovered. 2. Damage to calf muscles: If the exercise is excessive or not enough warm-up can cause damage to the calf muscles, which can cause pain in the calf after tiptoe, and can be accompanied by swelling of the calf muscles and other symptoms. 2. Ligament damage: due to excessive exercise, excessive, improper exercise or pressure smash impact and other reasons can cause ligament injury, or even ligament rupture, can appear after tiptoe calf pain symptoms, accompanied by localized swelling, subcutaneous bruising, and even joint mobility disorders and other symptoms. If tiptoe calf pain, rest does not relieve, it is recommended that the patient to the hospital in a timely manner, after a clear diagnosis of standardized treatment, so as not to delay the condition.