The concept of brain disease requiring surgery, which always sounds so scary, leaving behind sequelae and even death, has been deeply imprinted in most people’s minds; it is mentioned whenever we talk to patients or chat with friends. Brain tissue, like other tissues, can also give birth to tumors. At present, the first choice of treatment for tumors is still surgery, which can achieve complete resection of tumors while maximizing preservation of neurological functions, which is the goal of modern neurosurgery and also the concept of minimally invasive surgery in a broad sense. I remember in the 1960s, “open five dead four, the remaining one is a fool”, which became a ridiculing remark by the same profession. At that time, the diagnosis of intracranial tumors could only be made by neurologists with small hammers, which inevitably led to errors, and the surgical conditions at that time also affected the surgical results. The rapid development of medical imaging has taken us by surprise. In the 1980s and 1990s, CT and magnetic resonance imaging allowed us to see the real intracranial structure, tumor shape and growth pattern, and we were no longer confused about whether a tumor was born or not, and we could clearly determine the location of the tumor. One by one, the problems of deep brain tumors and even brainstem tumors have been overcome, one by one, the forbidden areas have been broken through, huge brain tumors have been removed, and patients still resume normal study and work, and gradually we no longer hear “Oh, you are lucky! We no longer hear the exclamation of “Oh, you are lucky!”. In the new century, technology is constantly innovating, CT has been upgraded, 64 and 256 rows are more powerful, continuous volume scanning, no more blind areas, 3D post-processing three-dimensional observation of intracranial tumor morphology, even the completion of vascular morphology reconstruction, non-invasive angiography has become a reality, magnetic resonance imaging MRI followed by many English abbreviation codes: FMRI, MRS, DTI, even non-professional doctors can not understand these abbreviations. PETCT combines isotope technology with CT to compare the rate of glucose metabolism to determine whether the tumor is malignant and whether it is metastatic. It solves almost all diagnostic problems and prepares the brain tumor for surgical treatment. Intraoperative images are like navigation when driving, guiding the direction at any time. In recent years, intraoperative MRI and mobile CT devices appear in the operating rooms of large hospitals, which can obtain intraoperative images; intraoperative ultrasound can likewise understand the situation during surgery, and the high-frequency probe can go beyond the brain parenchyma and ventricles after craniotomy without the obstruction of the skull, and can even go through the midline ultra to the opposite side, which can probe the tumor location and whether there is residual, simple and easy can be widely used in medium and above hospitals. The surgical microscope magnifies the tissues more than 10 times, clearly distinguishes the tumor tissues and blood vessels, achieves fine operation, and greatly reduces the harassment to normal tissues. The intraoperative electrophysiological detection organically combines cortical EEG, cortical evoked potentials, brainstem evoked potentials, somatosensory evoked potentials and myoelectricity, etc. The multi-channel real-time detection of limb movement, sensation, cranial nerve and peripheral nerve function, language function, urinary and fecal conditions, etc., ensures the successful removal of tumor and maximum preservation of neurological function. We really have to thank the times and the progress of science and technology. The times create heroes perhaps from the chaotic times, but technology and knowledge have made a generation of doctors and even masters. If anyone asks again, will opening a brain tumor make a person stupid? We can easily answer that it is just a joke.