Pediatric acromegaly may be caused by family inheritance, malnutrition, immune abnormality, heavy metal poisoning and other factors.
1. Family inheritance: 5% to 10% of pediatric patients with acromegaly have a family history, and the common mode of inheritance is mainly autosomal dominant.
2. Malnutrition: Reduced plasma vitamin B1 and vitamin B1 monophosphate in malnutrition may lead to pediatric acromegaly.
3. Immune abnormality: some patients have elevated cerebrospinal fluid immunoglobulin, positive anti-ganglioside antibody, and abnormal blood T cell number and function.
4. Heavy metal poisoning: some patients have increased aluminum content in plasma and cerebrospinal fluid, and long-term exposure to heavy metals may lead to pediatric acromegaly.
Pediatric acromegaly is a progressive neurodegenerative disease, once diagnosed, you need to consult the doctor as soon as possible, and actively cooperate with the doctor’s treatment.