Toothache in five-year-olds can be caused by deep caries, pulpitis, apical periodontitis, etc. It can be treated by indirect endodontics, root canal therapy, etc., and the affected tooth needs to be extracted if necessary. 1. Indirect endodontic treatment: five-year-old children are in the period of milk teeth, the ability to carry out oral cleaning is weak, easy to suffer from caries. When deep caries in milk teeth, there can be a transient pain of hot and cold stimulation. If the caries is close to the pulp cavity and there is no irreversible pulpitis, indirect endodontic treatment is feasible to protect the pulp. 2. Endodontics: The pulp angle of milk teeth is high, early infection of the pulp can occur, developing into pulpitis or even apical periodontitis. At this time, children may experience spontaneous pain. Root canal therapy can be used to remove the infected pulp from the root canal, relieve pain and promote the healing of periapical tissues. 3. Extraction of the affected teeth: at the age of 5 years, some milk teeth can appear physiological resorption, when the scope of the lesion of the affected tooth is large, such as to the remaining tissue of the tooth body is less valuable for retention, invasion of neighboring teeth, triggering interstitial infections, need to be extracted in a timely manner, so as to avoid the lesion continues to progress. Five-year-old children with toothache need to consult the stomatology department in a timely manner, to clarify the cause of the disease, to be treated.