The main treatment for H. pylori is a quadruple therapy, which consists of a proton pump inhibitor, a bismuth agent and two antibiotic drugs. Helicobacter pylori is a spiral, gram-negative, microaerobic bacteria. At present, the clinical commonly used radical quadruple therapy, commonly used proton pump inhibitors commonly used omeprazole, rabeprazole, etc.; bismuth commonly used bismuth pectin, bismuth citrate potassium, etc.; two antibiotics commonly used amoxicillin, clarithromycin, metronidazole or tinidazole, levofloxacin, furazolidone, etc., the course of treatment 10-14 days. The treatment of Helicobacter pylori is more difficult to take more drugs, each drug has a certain adverse reaction, if there is a significant adverse reaction after taking the drug, stop the drug in time and seek medical attention. If there is Helicobacter pylori infection, it is recommended to consult the gastroenterology department in a timely manner, under the guidance of the doctor regular use of medication, follow the doctor’s instructions to take medication, quit smoking and alcohol, avoid spicy and stimulating food, regular diet, avoid self-medication, delayed the condition, and pay attention to the rechecking of Helicobacter pylori test after stopping the drug for 1 month.