High alpha-fetoprotein lasting half a year may be due to physiological factors such as staying up late, pregnancy, or pathological factors such as cirrhosis, liver cancer, testicular cancer and other diseases of the liver or reproductive system. 1. Physiological factors: alpha-fetoprotein is a kind of glycoprotein synthesized by liver cells during fetal period, and the synthesis will be gradually reduced in adulthood, and the content of adult serum is generally <25ng/ml. when there are bad habits such as staying up late, working hard, drinking a lot of alcohol, etc., it may cause transient damage to liver, which will result in the synthesis of alpha-fetoprotein to restart, and cause the elevation of alpha-fetoprotein. When a woman is pregnant, the fetus synthesized alpha-fetoprotein will also enter the mother’s body, so that the serum alpha-fetoprotein of pregnant women is elevated, and usually will be gradually reduced after delivery. 2. Pathological factors: liver cirrhosis, acute and chronic hepatitis and other benign liver diseases, will make alpha-fetoprotein rise, but usually not more than 300ng/ml; when suffering from primary liver cancer and other malignant liver diseases, alpha-fetoprotein will be obviously elevated, and more than 400ng/ml; testicular cancer, ovary tumors, malignant teratomas, gonadal teratoblastomas, and other reproductive tumors will also make alpha-fetoprotein rise. Testicular cancer, ovarian tumor, malignant teratoma, gonadal teratoblastoma and other reproductive system tumors will also increase AFP. In addition, pancreatic cancer, stomach cancer, intestinal cancer, lung cancer and other malignant tumors will also lead to elevated alpha-fetoprotein. When high alpha-fetoprotein persists for half a year, it is recommended to consult a doctor in time to find out the cause of the disease and carry out targeted treatment so as not to delay the condition.