Coronary heart disease severe stenosis treatment mainly includes drug therapy, myocardial reperfusion therapy and so on. 1. Drug therapy: mainly includes antiplatelet drugs, lipid regulating drugs, anticoagulant drugs, coronary drugs. (1) Antiplatelet drugs: prevent thrombosis by inhibiting platelet aggregation, commonly used aspirin, clopidogrel and so on. (2) Lipid-regulating drugs: lowering blood lipids, stabilizing plaque, preventing plaque rupture, commonly used atorvastatin, resuvastatin and so on. (3) Anticoagulant drugs: inhibit coagulation factors to prevent thrombosis. Commonly used low molecular heparin, drotrecogin, etc. (4) Vasodilator drugs: dilate coronary artery, increase coronary blood flow to improve myocardial ischemia symptoms, commonly used nitroglycerin, isosorbide nitrate and so on. 2. Myocardial reperfusion therapy: mainly including stenting, thrombolysis, coronary artery bypass grafting. Severe stenosis of coronary artery should be evaluated by doctor according to the specific situation whether reperfusion therapy is needed. Severe stenosis of coronary artery disease is recommended to consult the hospital immediately and ask the doctor to guide the treatment. The above medications need to be applied under the guidance of a doctor to avoid adverse consequences.