When the symptoms of frozen shoulder are serious and affect the daily life and work, it is possible to take painkillers, but the following points must be noted: First, it is advocated to take non-steroidal anti-inflammatory drugs, painkillers with the purpose of anti-inflammation. The principle of action of non-steroidal anti-inflammatory drugs is mainly to inhibit the synthesis of prostaglandins in the body to achieve the purpose of relieving inflammation and eliminating pain. Second, when the effect of the use of non-steroidal topical drugs is not good, you can take short-term opioid receptor antagonists, such as aminophenol oxycodone, but pure painkillers are not recommended for long-term use by patients. Third, no matter which class of drugs must pay attention to the side effects, such as non-steroidal anti-inflammatory drugs, peptic ulcer, asthma or previous cardiovascular disease, coronary heart disease, heart attack, angina pectoris patients should be used with caution. Opioid receptor antagonists are CNS-acting drugs that should be used with caution in patients with chronic respiratory infections or who have had a stroke, with the possibility of respiratory depression.