Taking entecavir for 1 month glutamine transaminase 400 is not normal if the transaminase is in the normal range before taking the drug.If the original transaminase is high, it may be normal. 1. Normal aminotransferase before taking the drug: the normal value of alanine aminotransferase is 0~40U/L. If the aminotransferase before taking the drug is normal, and the alanine aminotransferase is 400 after 1 month, which is abnormal, it is recommended to go to the hospital for examination in time and change the drug. 2. high aminotransferase before taking the drug: entecavir usually needs to be taken for a long time, usually need to be used for 48 weeks to have a good improvement, ghrelin can be restored to about 80%, taking 1 month can’t make ghrelin drop immediately, so taking entecavir 1 month ghrelin is 400 may be a normal situation, the need for regular rechecking of liver function during the period of treatment and consult the doctor’s advice. Entecavir is mainly used for the treatment of chronic adult hepatitis B with active viral replication, persistent elevation of serum alanine aminotransferase, and liver lesions. The drug is contraindicated for those who are allergic to entecavir, and consult your doctor promptly if you have any discomfort.