Patients with thyroid nodules who do not have contraindications to orlistat can take orlistat. Orlistat is a gastrointestinal lipase inhibitor that inhibits the absorption of triglycerides, which in turn inhibits caloric intake and ultimately serves to control body weight; it can be used in the treatment of patients who are obese or characterized as overweight. It is contraindicated in pregnant women, hypersensitivity to orlistat or any of the components of the drug preparation, chronic malabsorption syndrome, cholestasis, and patients with organic obesity (e.g. hypothyroidism). Therefore, patients with thyroid nodules who do not have contraindications to orlistat can take this drug for treatment. Adverse reactions such as increased gastrointestinal gas, urgency of stools, fatty (oily) stools, increased frequency of stools, abdominal pain, abdominal discomfort, gastrointestinal flatulence, watery stools, itching, rash, hives, etc., may occur with the use of the drug. Patients with thyroid nodules who require treatment with orlistat should use the medication under the supervision of a doctor.