Ankylosing spondylitis is a chronic progressive inflammatory disease with sacroiliac and spinal mid-axis arthropathy as the main lesion. It manifests clinically as sacroiliac arthritis, spinal and peripheral arthritis, and some patients may have varying degrees of eye, lung, cardiovascular, renal, neurological and other organ damage. The main goal of treatment is to control the symptoms of pain and stiffness and to slow down the progression of the disease and protect joint function. Treatment includes patient education, physical therapy, medication and surgical treatment. 1. General treatment: patient education is carried out. And exercise the mobility of the cervical, thoracic and lumbar spine, avoid excessive weight bearing and strenuous exercise. Should sleep on a hard bed, low pillow supine, avoid positions that promote flexion deformity. Physical exercise, can prevent the occurrence of some deformities, muscle atrophy, osteoporosis, etc. 2, physical therapy: is the treatment of ankylosing spondylitis. You can use ultrashort wave, pulse magnetic therapy, moxibustion, acupuncture, hot water baths, etc.. Because these methods can increase the circulation of blood in the body, can choose to use. 3, drug therapy: for example, including non-steroidal anti-inflammatory drugs, is one of the most commonly used drugs for the treatment of ankylosing spondylitis. Can effectively as well as quickly relieve the body’s pain, for reducing the role of inflammation. Anti-rheumatic drugs, anti-tumor necrosis factor (TNF) antagonists, etc., are effective in the treatment of ankylosing spondylitis. However, the specific medication needs to be under the guidance of a clinician. 4, surgical treatment: in order to improve joint function, surgical treatment such as arthroplasty and vertebral cuneiform osteotomy can be chosen. Severe spinal deformities can be surgically corrected. Therefore, the treatment of ankylosing spondylitis, mainly including the above aspects, the specific treatment also according to the patient’s situation to choose.