At present, China’s Food and Drug Administration has only approved the listing of two kinds of botulinum toxin: one is the domestic “Hengli”, the second is the imported “BOTOX”. The young woman because of the injection of “thinning the face” “thinning the legs”, resulting in breathing difficulties, can not walk and other toxic reactions, have entered the rescue room, and even used the ventilator. In the hospital met several patients who claimed to have injected “Botox” in the beauty salon and sent to the hospital for emergency treatment. Doctors said that similar cases have been received in the past two months, and it is suspected that a batch of fake botulinum toxin has entered the market. In the neurology ward, a female college student collapsed on a bed. She was admitted to the hospital by emergency, and by the time she arrived, she was having difficulty eating and breathing, her speech had changed, her body was weak, and she was having difficulty walking. The emergency room called for an emergency consultation with doctors from dermatology and neurology. The female patient claimed that she had been injected with Korean “face slimming injections” at a beauty salon. In addition to her, the ward also houses two female patients who were also injected with Korean “face slimming” “leg slimming” in the beauty salon. The product box provided by the patient, written in Korean and English, is not the packaging of the regular hospital use of botulinum toxin. In neurology, Botox is a good drug for treating movement disorders, mainly for facial muscle spasm, eyelid spasm, spastic squint, chronic headache, various types of dystonia or tremor. In fact, botulinum toxin has been used for more than 30 years to treat various dystonia disorders. Currently, botulinum toxin is approved for clinical use in more than 80 countries, with as many as 22 indications. As a potent biotoxin, Botox can antagonize excessive muscle spasm at the injection site, and it is based on this principle that cosmetology and dermatology use it for “slimming the face” and “slimming the arms”, etc. However, if Botox is not injected correctly, muscle If Botox is not injected correctly, muscle weakness and even breathing disorders may occur. Doctors involved in botulinum toxin injections in regular hospitals talk about the type of botulinum toxin, the location of the injection and the amount of the injection. However, the current poisoning cases have made them doubt the authenticity of the Botox injections. At present, China’s Food and Drug Administration has approved the listing of only two kinds of Botox: one is the domestic “Hengli”, and the other is the imported “BOTOX”. The pharmaceutical wholesale purchasing enterprises will only provide the regular Botox to medical institutions with medical qualifications, never to individuals or beauty institutions, etc. Doctors have talked about the clinical application of botulinum toxin is still mature, safe, now presumed to lead to poisoning for three reasons: 1, injected with fake botulinum toxin; 2, the injector illegal practice of medicine, injection target error – the correct botulinum toxin should be muscle injection, but the beautician may inject it into the blood vessels; 3, the dose is not correct. Doctors say that the dose of Botox is not well controlled, it is likely to reach the “lethal dose”, which is very dangerous. Botulinum toxin is a special biological agent, transportation or cold chain problems may make the drug structure is unstable, toxic changes. If it is fake botulinum toxin, the dose is not well controlled. Together with the injection by unqualified people, the risk is doubled. Currently, these emergency admissions require antitoxin treatment. As a special biological agent, only the domestic botulinum toxin “Hengli” company has the relevant antitoxin drugs, Ruijin Hospital has applied for drug transfer through the CDC. According to reports, antitoxin treatment has a window of time to pay attention to, 2 weeks to use the drug to be effective, more than the time completely have to rely on the patient’s own metabolism of toxins in the body, how much can be metabolized, how many side effects left behind, which is unknown. Unfortunately, a patient at Ruijin Hospital is allergic to antitoxin drugs, which makes treatment again into difficulties, the hospital is trying to find ways to actively treat.