Patients with gallstones should not eat melon seeds. The causes of gallstones are now thought to be significantly correlated with imbalance of bile acid cholesterol dissolution, biliary obstruction, bacterial infection, and gallbladder contraction hypofunction. Bile is produced by the liver and concentrated in the gallbladder. After eating, the gallbladder contracts and the bile is discharged through the common bile duct into the intestinal lumen, where it is mainly involved in the digestion and absorption of fats. The diet of gallstone patients requires a low-fat, low-cholesterol diet, melon seeds is a relatively high fat content of food, after eating will increase the burden of the gallbladder contraction function, so gallstone patients should not eat melon seeds. At the same time, eating melon seeds may lead to increased secretion of gastrointestinal fluids, which may indirectly stimulate the gallbladder contraction and cause gallstones induced biliary colic symptoms, so patients with gallstones should not eat melon seeds.